THE BEHAVIORAL TERATOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRING’S OF ALBINO RATS

THE BEHAVIORAL TERATOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRING’S OF ALBINO RATS

ABSTRACT
The concern of this research was the Behavioral teratogenic erects of cimetidine on the offspring of Albino Rats. It was designed to test if cimetidine will
have erect on spring born to mothers who took cimetidine during gestation period. Sample of this study comprises of 3 pregnant albino rats which were
randomly assigned into three (3) groups, grove A B and C. group A is the control group that did not receive any treatment why group B and C were the experimental group that received the experimental treatment. The experimental group B was given 2ml of cimetidine injection with caroler daily i.e. 1ml of cimetidine injection in the morning another 1ml of cimetidine injection in the evening. The experimental group C was given 4ml of cimetidine injection with a caroler daily i.e. 2ml of cimetidine injection in the morning and another 2ml of cimetidine injection in the evening their gestation period. 19 pups littered by the 3 female albino rats of both the control group and experimental groups were also used as the subject in the study. Three hypothesis were advanced and
tested in this study, Hypothesis one which stated that there will be a significant dierence
between the offspring of albino rats who were injected with
cimetidine to those morn to mothers who were not injected with cimetidine on a T-maze test. This was confirmed [DF (2,9)=33.96,P<.01]. hypothesis two which stated that offspring of albino rats who were injected with cimetidine during gestation will significantly perform low on the performance ability test (classical maze test) than those born to mother who were not injected was also tasted and confirmed [DF (2,9)=14/15, P<. 05]. The third hypothesis which stated that offspring born to albino rats who were injected with cimetidine during gestation will have a significant low birth weight than those offspring
of mother who were not injected with cimetidine during gestation. Data was analyzed using one way analysis of variance (ANOVA). It was therefore recommending that women who used cimetidine should stay away from it uses during pregnancy, because it is a teratogenic agent and could cause harm or impairment to their offspring.

CHAPTER ONE
INTRODUCTION
The guinea pig (cava parellus), also called cavy, and the genus cavia. Despite their common name, these animals are not in the pig family, nor are they from
guinea, they originated in the Andes, and earlier studies based on biochemistry and hybridization suggested they are domestic descendants of a closely
related species of cavy such as Cavia aperea, C. fulgida, or c. tschudii and therefore do not exist naturally in the wild (Ounnum 2010).
Guinea pigs were popular laboratory animals until the later 20th century; about 2.5 million guinea pigs were used annually in the U.S. for research in the
1960s. (Gad, 2007), but that total decreased to about 375,000 by the mid-1990s. as of 20007, they constitute approximately 2% of the current total of labory
animals in the past they were widely used to standardize vaccines and antiviral agent they were also one employed in studies on the production of antibodies in response to extreme allergic reaction or anaphylaxis.

THE BEHAVIORAL TERATOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRING’S OF ALBINO RATS