ASSAY OF VARIOUS BRANDS OF FERROUS SULPHATE TABLETS USING AQUEOUS TITRIMETRIC METHOD

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ASSAY OF VARIOUS BRANDS OF FERROUS SULPHATE TABLETS USING AQUEOUS TITRIMETRIC METHOD

ABSTRACT

Ferrous sulphate tablet is an oral salt of iron. It is the cheapest form of medicinal iron supplement and it is used in the treatment of iron deficiency anaemia. Iron deficiency is one of the world’s most common nutritional deficiency diseases, affecting infants, children and especially pregnant women as well as lactating mothers. Various brands of ferrous sulphate tablets were assayed to confirm the amount of iron content as claimed by the manufacturers, so as to ensure maximum therapeutic effects during clinical use. Seven different brands of ferrous sulphate tablets by different manufacturers which were obtained from various pharmacy outlets in Delta State and Anambra of Nigeria were assayed using the titrimetric method of analysis as described by the British Pharmacopoeia (BP) 2012. They were also tested for uniformity of weight by the method stated in the BP. All the samples were found to contain iron content in an amount within the percentage content of 95.0% – 105.0%. Also, no variation was found in the weight of the samples. Therefore, these brands when administered can bring about maximum therapeutic benefits during clinical use.

CHAPTER ONE

1.0 INTRODUCTION AND LITERATURE REVIEW

1.1 BACKGROUND

Assay methods in pharmaceutical chemistry are essential to control the quality of pharmaceutical product, as well as the quantity of the active pharmaceutical ingredients in a formulated product. To do this, a whole arsenal of chemical, physicochemical, biological, biopharmaceutical and automated analytical techniques is employed for determining the identity, purity, content, stability, safety and efficacy of drugs and their formulations. ^[1]

Different forms of iron are usually prescribed by physicians for patients and they rely on the amount of iron claimed on the label. Determination of the precise amount of iron (II) contained in ferrous sulphate tablet is therefore important. Ferrous sulphate tablet has been assayed using various analytical methods.

ASSAY OF VARIOUS BRANDS OF FERROUS SULPHATE TABLETS USING AQUEOUS TITRIMETRIC METHOD

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