A NEW LA(III)-MOF FOR EFFICIENT DYE PHOTODEGRADATION AND PROTECTIVE EFFECT ON EXERCISE PAIN AFTER TOTAL KNEE ARTHROPLASTY BY REDUCING NICOTINIC ACETYLCHOLINE RECEPTORS EXPRESSION

The creation of multifunctional metal-based coordination complexes has been a hot topic in the fields of material science and biomedicine for their great potential application, metal–organic frameworks (MOFs) process the features of both coordination complexes and semiconductor materials might fit the requirements of the targeted materials. In this study, the assembly of the light-harvesting linker with La(III) ion produced a three-dimensional MOF [La 2 (adda) 3 (H 2 O) 2 ] n ( 1 ) (H 2 adda = (2E,2′E)-3,3′-(anthracene-9,10-diyl) diacrylic acid), which could be applied as an effective catalyst for the Rhodamine B’s degradation. The treatment effect of compound 1 on exercise pain after total knee arthroplasty (TKA) on rat model was evaluated. The times of rats licking the surgery tissues was counted in the analgesic animal model. The content of the nicotinic acetylcholine receptors on presynaptic membrane was determined by RT-PCR. The possible binding interaction of the drug-like La(III) complex to the DNA structure has been further reviewed by molecular docking simulation.